IRF AND STAT TRANSCRIPTION FACTORS - FROM BASIC BIOLOGY TO ROLES IN INFECTION, PROTECTIVE IMMUNITY, AND PRIMARY IMMUNODEFICIENCIES

IRF and STAT Transcription Factors - From Basic Biology to Roles in Infection, Protective Immunity, and Primary Immunodeficiencies

The induction and action of type I interferon (IFN) is of fundamental importance in human immune defenses toward microbial pathogens, particularly viruses.Basic discoveries within the molecular and cellular signaling pathways regulating type I IFN induction and downstream actions have shown the essential role of the IFN regulatory factor (IRF) and

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Isofront in the Eastern Siberian Region (1930s)

The history of the formation of the organization of the Union of Soviet Artists in the remote regions of the country has not been fully studied, but it is of interest for understanding the features of the development of domestic fine art.The article discusses the process of formation of branches of the East Siberian Regional Riding Jackets Union of

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